Fig. 1 · Structure
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Sacubitril hemicalcium salt
NEP Inhibitor
Sacubitril hemicalcium salt is a potent neprilysin (NEP) inhibitor, demonstrating an IC50 of 5 nM. This compound plays a critical role in heart failure research and is a key component of the therapeutic agent LCZ696. Its mechanism of action involves the elevation of natriuretic peptides, contributing to improved cardiovascular function and offering insights into novel heart failure treatments.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1369773-39-6 |
| Applications | NEP Inhibitor |
| Formula | C24H28Ca0.5NO5 |
| Molecular Weight | 430.52 |
| Synonyms | AHU-377 hemicalcium salt |
| SMILES | O=C(CCC([O-])=O)N[C@H](CC1=CC=C(C2=CC=CC=C2)C=C1)C[C@@H](C)C(OCC)=O.[0.5Ca2+] |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.