Fig. 1 · Structure
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SAHA-BPyne
ABPP Probe
SAHA-BPyne is an activity-based protein profiling (ABPP) probe designed for the detection of histone deacetylase (HDAC) activity. This compound covalently labels proximal proteins upon photoactivation, allowing for enhanced profiling of HDAC dynamics. SAHA-BPyne exhibits inhibitory activity against HDAC in HeLa nuclear lysates, offering an IC50 of less than 5 μM, making it a valuable tool for research applications involving epigenetics and protein modification studies.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 930772-88-6 |
| Applications | ABPP Probe |
| Formula | C27H31N3O5 |
| Molecular Weight | 477.55 |
| SMILES | O=C(NO)CCCCCCC(NC1=CC=C(C(C2=CC=C(NC(CCCC#C)=O)C=C2)=O)C=C1)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.