Fig. 1 · Structure
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Sapropterin
PAH cofactor
Sapropterin, also known as (6R)-Tetrahydro-L-biopterin, serves as an essential cofactor for phenylalanine hydroxylase (PAH), playing a crucial role in the metabolism of phenylalanine. Its primary biological activity includes the reduction of blood phenylalanine levels, making it a valuable reagent in research on phenylketonuria (PKU). Additionally, Sapropterin has been implicated in the exacerbation of experimental autoimmune encephalomyelitis (EAE), providing insights into its potential effects on autoimmune conditions.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 62989-33-7 |
| Applications | PAH cofactor |
| Formula | C9H15N5O3 |
| Molecular Weight | 241.25 |
| Synonyms | (6R)-BH4; (6R)-Tetrahydro-L-biopterin |
| SMILES | O=C1C2=C(NC(N)=N1)NC[C@](N2)([H])[C@@H](O)[C@@H](O)C |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.