Fig. 1 · Structure
Documents & Downloads
SARS-CoV-2 3CLpro-IN-5
3CLpro Inhibitor
SARS-CoV-2 3CLpro-IN-5 is a potent covalent inhibitor of the 3C-like protease (3CLpro), demonstrating impressive inhibitory activity with an IC50 value of 3.8 nM. With a reported oral bioavailability of 9.0%, this compound is particularly relevant for studying the therapeutic potential against coronavirus disease 2019 (COVID-19). Its mechanism of action makes it a valuable tool for researchers investigating the molecular underpinnings of SARS-CoV-2 replication and pathogenesis.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2913186-57-7 |
| Applications | 3CLpro Inhibitor |
| Formula | C22H26ClF2N5O4 |
| Molecular Weight | 497.92 |
| SMILES | FC1=CC=CC2=C1C=C(C(N[C@H](C(NN(C([C@@](F)([H])Cl)=O)C[C@H]3C(NCC3)=O)=O)CC(C)C)=O)N2 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.