Fig. 1 · Structure
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SARS-CoV-2 nsp13-IN-4
nsp13 Inhibitor
SARS-CoV-2 nsp13-IN-4 is a selective inhibitor targeting the nsp13 helicase, demonstrating potent inhibition of single-stranded DNA and ATPase activity with an IC50 value of 57 μM. With a molecular weight of less than 450 Da, this small-molecule compound is positioned for use in research applications focused on antiviral therapeutics against SARS-CoV-2. Its mechanism highlights a promising avenue for the development of broad-spectrum antiviral agents.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 923140-39-0 |
| Applications | nsp13 Inhibitor |
| Formula | C20H15BrN4O |
| Molecular Weight | 407.26 |
| SMILES | CC1=NC2=NC(C3=CC=C(C=C3)NC(C4=CC=CC(Br)=C4)=O)=CN2C=C1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.