Fig. 1 · Structure
Documents & Downloads
SARS-CoV-2 nsp3-IN-1
Mac1 Inhibitor
SARS-CoV-2 nsp3-IN-1 is an inhibitor of the Mac1 (SARS-CoV-2 nsp3 macrodomain), exhibiting an IC50 value of 6.1 μM. This compound effectively inhibits the ADP-ribosylhydrolase activity of Mac1, demonstrating a significant selectivity for coronavirus macrodomains, particularly the Mac1 domain of SARS-CoV-2. It serves as a valuable tool for research into the mechanisms of SARS-CoV-2 and the development of antiviral strategies.
In Stock
Free Aliquoting for Your Order
Tell us your preferred amount per vial. We’ll confirm the options.
Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2892105-43-8 |
| Applications | Mac1 Inhibitor |
| Formula | C17H15N5O2 |
| Molecular Weight | 321.33 |
| SMILES | OC([C@H](CC1=CNC2=C1C=CC=C2)NC3=NC=NC4=C3C=CN4)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.