Documents & Downloads

SARS-CoV-2 PLpro-IN-2

PLpro Inhibitor

SARS-CoV-2 PLpro-IN-2 is a potent inhibitor of the SARS-CoV-2 papain-like protease (PLpro), exhibiting a high selectivity with an IC50 of 0.06 μM. This compound effectively blocks viral replication and prevents immune evasion, demonstrating antiviral efficacy with an EC50 of 2.9 μM in HeLa-ACE2 cells. SARS-CoV-2 PLpro-IN-2 serves as a valuable tool in COVID-19 research, facilitating investigations into therapeutic strategies against the virus.

Out of Stock

Free Aliquoting for Your Order

Tell us your preferred amount per vial. We’ll confirm the options.

Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	1581755-42-1
Applications	PLpro Inhibitor
Formula	C₂₅H₂₇ClN₂O
Molecular Weight	406.95
SMILES	C[C@@H](N1CCC(C(NCC2=CC=C(Cl)C=C2)=O)CC1)C3=CC=CC4=CC=CC=C43

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.