SB-1436 is a potent cholinesterase inhibitor targeting acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) with IC50 values of 0.176 μM and 0.37 μM, respectively. It inhibits these enzymes in a non-competitive manner, exhibiting Kis of 0.046 μM for AChE and 0.115 μM for BChE. Additionally, SB-1436 significantly reduces the self-aggregation of amyloid-beta (Aβ), making it a valuable tool for research in neurological diseases and related therapeutic applications.
SB-1436 is a potent cholinesterase inhibitor targeting acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) with IC50 values of 0.176 μM and 0.37 μM, respectively. It inhibits these enzymes in a non-competitive manner, exhibiting Kis of 0.046 μM for AChE and 0.115 μM for BChE. Additionally, SB-1436 significantly reduces the self-aggregation of amyloid-beta (Aβ), making it a valuable tool for research in neurological diseases and related therapeutic applications.
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