Fig. 1 · Structure
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SB 206553
5-HT2C Inverse Agonist
SB 206553 is an inverse agonist of the 5-HT2C receptor, demonstrating significant biological activity with pKi values of 5.6 nM, 7.7 nM, and 7.8 nM for the 5-HT2A, 5-HT2B, and 5-HT2C receptors, respectively, in HEK-293 and CHO-K1 cell lines expressing human recombinant receptors. This compound has been shown to attenuate methamphetamine-seeking behavior in rat models. SB 206553 is valuable for research into psychostimulant abuse disorders and the underlying mechanisms of serotonergic signaling.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inverse Agonist |
| CAS Number | 158942-04-2 |
| Applications | 5-HT2C Inverse Agonist |
| Formula | C17H16N4O |
| Molecular Weight | 292.34 |
| SMILES | O=C(N1CCC2=C1C=C3C(N(C)C=C3)=C2)NC4=CC=CN=C4 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.