SB-277011 dihydrochloride

Catalog No.: A21353

dopamine D3 receptor antagonist

SB-277011 dihydrochloride

SB-277011 dihydrochloride Chemical Structure

CAS NO. 1226917-67-4

SB-277011 dihydrochloride (SB-277011A dihydrochloride) is a potent, selective, orally bioavailable and brain penetrate dopamine D3 receptor antagonist, with pKis of 8.0, 6.0, <5.2 and 5.9 for D3, D2, 5-HT1B, and 5-HT1D receptors, respectively.

Availability: In stock

Package Price Qty
1 mg

Regular Price: $320.00

Special Price $256.00

5 mg

Regular Price: $960.00

Special Price $768.00

10 mg

Regular Price: $1,600.00

Special Price $1,280.00

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Biological Activity

SB-277011 dihydrochloride (SB-277011A dihydrochloride) is a potent, selective, orally bioavailable and brain penetrate dopamine D3 receptor antagonist, with pKis of 8.0, 6.0, <5.2 and 5.9 for D3, D2, 5-HT1B, and 5-HT1D receptors, respectively.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 19.55 mL 97.75 mL 195.51 mL
0.5 mM 3.91 mL 19.55 mL 39.1 mL
1 mM 1.96 mL 9.78 mL 19.55 mL
5 mM 0.39 mL 1.96 mL 3.91 mL

*The above data is based on the productmolecular weight 511.49. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A21353
Actions Antagonist
CAS No. 1226917-67-4
Formula C28H32Cl2N4O
M. Wt 511.49
Purity >98%
Synonyms SB-277011A dihydrochloride, SB277011, SB 277011, SB 277011A, SB277011A
SMILES O=C(C1=CC=NC2=CC=CC=C12)N[[email protected]]3CC[[email protected]](CCN4CC5=C(C=C(C#N)C=C5)CC4)CC3.[H]Cl.[H]Cl
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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