SB 414240 is a selective neurokinin-2 receptor (NK-2R) antagonist, exhibiting a Ki of 193 nM for human NK-2R and a much higher Ki of 1 nM for human NK-3R. This compound demonstrates a lack of binding affinity for the human μ-opioid receptor (hMOR). SB 414240 is particularly valuable for research focused on neurological diseases, enabling studies on the modulation of neurokinin pathways in various neurological contexts.
SB 414240 is a selective neurokinin-2 receptor (NK-2R) antagonist, exhibiting a Ki of 193 nM for human NK-2R and a much higher Ki of 1 nM for human NK-3R. This compound demonstrates a lack of binding affinity for the human μ-opioid receptor (hMOR). SB 414240 is particularly valuable for research focused on neurological diseases, enabling studies on the modulation of neurokinin pathways in various neurological contexts.
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