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SB 414240

NK-2R Antagonist

SB 414240 is a selective neurokinin-2 receptor (NK-2R) antagonist, exhibiting a Ki of 193 nM for human NK-2R and a much higher Ki of 1 nM for human NK-3R. This compound demonstrates a lack of binding affinity for the human μ-opioid receptor (hMOR). SB 414240 is particularly valuable for research focused on neurological diseases, enabling studies on the modulation of neurokinin pathways in various neurological contexts.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Antagonist
CAS Number	272104-60-6
Applications	NK-2R Antagonist
Formula	C₃₃H₄₄N₄O
Molecular Weight	512.73
SMILES	O=C(N[C@@H](C)C(C)(C)C)C1=C(C(C2=CC=CC=C2)=NC3=CC=CC=C13)CN4CCC(CC4)N5CCCCC5

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.