Fig. 1 · Structure
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SB-747651A dihydrochloride
MSK1 Inhibitor
SB-747651A dihydrochloride is a potent ATP-competitive inhibitor of mitogen- and stress-activated kinase 1 (MSK1), exhibiting an IC50 of 11 nM. This compound also demonstrates inhibitory activity against PRK2, RSK1, p70S6K, and ROCK-II. It is a valuable tool for investigating inflammatory pathways and the broader implications of kinase regulation in cellular response mechanisms.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1781882-72-1 |
| Applications | MSK1 Inhibitor |
| Formula | C16H24Cl2N8O |
| Molecular Weight | 415.32 |
| SMILES | NC1=NON=C1C(N2CC)=NC3=C2C(CNC4CCNCC4)=CN=C3.[H]Cl.[H]Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.