Fig. 1 · Structure
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SB-747651A
MSK1 Inhibitor
SB-747651A is an ATP-competitive inhibitor of mitogen- and stress-activated kinase 1 (MSK1) with an IC50 of 11 nM. Additionally, it demonstrates inhibitory activity against PRK2, RSK1, p70S6K, and ROCK-II. This compound is valuable for studying inflammation and related signaling pathways, contributing to research on cellular responses to stressors and potential therapeutic targets.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 607372-46-3 |
| Applications | MSK1 Inhibitor |
| Formula | C16H22N8O |
| Molecular Weight | 342.40 |
| SMILES | NC1=NON=C1C(N2CC)=NC3=C2C(CNC4CCNCC4)=CN=C3 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.