SC209, a 3-aminophenyl hemiasterlin derivative, targets tubulin as an ADC cytotoxin. This compound demonstrates reduced efflux potential through the P-glycoprotein 1 pump when compared to other tubulin-targeting agents, enhancing its efficacy in therapeutic applications. SC209 exhibits significant antitumor activity and is suitable for the synthesis of antibody-drug conjugates (ADCs), making it a valuable reagent in cancer research.
SC209, a 3-aminophenyl hemiasterlin derivative, targets tubulin as an ADC cytotoxin. This compound demonstrates reduced efflux potential through the P-glycoprotein 1 pump when compared to other tubulin-targeting agents, enhancing its efficacy in therapeutic applications. SC209 exhibits significant antitumor activity and is suitable for the synthesis of antibody-drug conjugates (ADCs), making it a valuable reagent in cancer research.
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