Fig. 1 · Structure
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SCH 206272
Tachykinin (NK) Receptor Antagonist
SCH 206272 is a selective antagonist of tachykinin (NK) receptors, effectively inhibiting binding at human NK(1), NK(2), and NK(3) receptors with Ki values of 1.3, 0.4, and 0.3 nM, respectively. This compound demonstrates significant biological activity in modulating neurokinin signaling pathways, making it valuable in research applications related to pain, anxiety, and other tachykinin-related disorders. Additionally, SCH 206272 is orally active, facilitating its use in in vivo studies.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 226915-43-1 |
| Applications | Tachykinin (NK) Receptor Antagonist |
| Formula | C33H41Cl4N5O4 |
| Molecular Weight | 713.52 |
| SMILES | O=C(C1=CC(Cl)=CC(Cl)=C1)N(C)C/C([C@@H](C2=CC(Cl)=C(C=C2)Cl)CCN3CCC(N4C([C@H](CCC4)CC(NC)=O)=O)CC3)=N\OC |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.