Fig. 1 · Structure
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SDUY038
SHP2 Inhibitor
SDUY038 is an allosteric inhibitor of SHP2, demonstrating an IC50 of 1.2 μM and a KD of 0.29 μM. This compound exhibits broad antitumor activity, with IC50 values ranging from 7 to 24 μM, by effectively suppressing pERK expression. Additionally, SDUY038 has a half-life of 3.95 hours when administered orally, making it a valuable tool for studies in cancer research and signaling pathways.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2892720-11-3 |
| Applications | SHP2 Inhibitor |
| Formula | C17H18Cl2N2O2S |
| Molecular Weight | 385.31 |
| SMILES | O=C(N1CCC(C)(CC1)N)C2=CC=C(SC3=C(Cl)C(Cl)=CC=C3)O2 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.