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Selnoflast calcium

NLRP3 Inhibitor

Selnoflast calcium is a selective and reversible small molecule inhibitor targeting the NLRP3 inflammasome. It effectively suppresses the release of IL-1β in response to NLRP3 activation, particularly in human monocyte-derived macrophages associated with Alzheimer's disease. This compound holds potential for advancing research in Alzheimer's as well as other systemic inflammatory diseases, including ulcerative colitis and chronic obstructive pulmonary disease.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	2887416-19-3
Applications	NLRP3 Inhibitor
Formula	C₂₀H₂₉N₃O₃S.xCa
Synonyms	Somalix calcium; RO-7486967 calcium; IZD334 calcium
SMILES	O=C(NS(=O)(C1CCN(CC1)CC)=O)NC2=C(CCC3)C3=CC4=C2CCC4.[Ca]

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.