Setileuton tosylate is a potent inhibitor of 5-lipoxygenase, effectively blocking the oxidation of arachidonic acid by recombinant human 5-LO. This compound demonstrates significant activity in reducing the production of leukotriene B4 (LTB4) in calcium ionophore-stimulated human whole blood, with IC50 values of 3.9 nM and 52 nM, respectively. Setileuton tosylate is valuable in research applications related to inflammatory pathways and leukotriene synthesis.
Setileuton tosylate is a potent inhibitor of 5-lipoxygenase, effectively blocking the oxidation of arachidonic acid by recombinant human 5-LO. This compound demonstrates significant activity in reducing the production of leukotriene B4 (LTB4) in calcium ionophore-stimulated human whole blood, with IC50 values of 3.9 nM and 52 nM, respectively. Setileuton tosylate is valuable in research applications related to inflammatory pathways and leukotriene synthesis.
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