Fig. 1 · Structure
Documents & Downloads
Setileuton tosylate
Cat. No.
A76497
CAS
1137737-87-1
Lipoxygenase Inhibitor
Setileuton tosylate is a potent inhibitor of 5-lipoxygenase, effectively blocking the oxidation of arachidonic acid by recombinant human 5-LO. This compound demonstrates significant activity in reducing the production of leukotriene B4 (LTB4) in calcium ionophore-stimulated human whole blood, with IC50 values of 3.9 nM and 52 nM, respectively. Setileuton tosylate is valuable in research applications related to inflammatory pathways and leukotriene synthesis.
In Stock
Free Aliquoting for Your Order
Tell us your preferred amount per vial. We’ll confirm the options.
Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1137737-87-1 |
| Applications | Lipoxygenase Inhibitor |
| Formula | C29H25F4N3O7S |
| Molecular Weight | 635.58 |
| Synonyms | MK-0633 tosylate |
| SMILES | O=S(O)(C1=CC=C(C=C1)C)=O.O=C2C=C(C3=CC=C(C=C3)F)C4=CC=C(CNC5=NN=C([C@](CC)(O)C(F)(F)F)O5)C=C4O2 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.