Fig. 1 · Structure
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SHP099 monohydrochloride
SHP2 Inhibitor
SHP099 monohydrochloride is a selective inhibitor of the SHP2 protein tyrosine phosphatase, demonstrating an IC50 of 70 nM. This compound is orally bioavailable, making it suitable for in vivo studies. SHP099 has been primarily applied in cancer research, where it shows potential in modulating immune responses and enhancing the efficacy of various therapeutic approaches.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2200214-93-1 |
| Applications | SHP2 Inhibitor |
| Formula | C16H20Cl3N5 |
| Molecular Weight | 388.72 |
| SMILES | NC1=NC(N2CCC(C)(N)CC2)=CN=C1C3=CC=CC(Cl)=C3Cl.Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.