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SHP2-IN-14

SHP2 Allosteric Inhibitor

SHP2-IN-14 is a potent allosteric inhibitor of SHP2, displaying an IC50 of 7 nM. This compound demonstrates significant anti-tumor activity, effectively inhibiting tumor progression in NCI-H358 tumor-bearing mice. Moreover, SHP2-IN-14 showcases favorable pharmacokinetic properties, contributing to its potential utility in cancer research and therapeutic applications.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	2673400-91-2
Applications	SHP2 Allosteric Inhibitor
Formula	C₂₂H₂₀Cl₂N₈O
Molecular Weight	483.35
SMILES	O=C(C1=C2C(C3=C(Cl)C(Cl)=NC=C3)=NNC2=NC(N4CCC(C5=CC=CC=C5)(N)CC4)=N1)N

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.