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SHP2-IN-22

SHP2 Inhibitor

SHP2-IN-22 is an allosteric inhibitor of SHP2, demonstrating an IC50 value of 17.7 nM. This compound effectively inhibits the proliferation, migration, and invasion of MIA PaCa-2 pancreatic cancer cells, making it a valuable tool in cancer research. SHP2-IN-22 is particularly relevant for investigations involving KRAS mutant cancers, providing insights into targeted therapeutic strategies.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	2802453-88-7
Applications	SHP2 Inhibitor
Formula	C₂₃H₂₂Cl₂N₈O
Molecular Weight	497.38
SMILES	N/C(N1CCN(CC1)C2=CN=C(C(N)=N2)C3=CC=CC(Cl)=C3Cl)=N\C4=CC(OC)=C(C=C4)C#N

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.