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SHP2-IN-23

SHP2 Inhibitor

SHP2-IN-23 is a potent inhibitor of the SHP2 protein, exhibiting an IC50 of 38 nM and demonstrating outstanding in vivo efficacy and pharmacokinetic properties. This compound effectively inhibits ERK phosphorylation with an IC50 of 5 nM, making it a valuable tool for research applications targeting cellular signaling pathways and cancer biology. Its oral bioavailability facilitates its use in preclinical studies to investigate the therapeutic potential of SHP2 modulation.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	2415989-91-0
Applications	SHP2 Inhibitor
Formula	C₂₄H₂₃ClN₈S
Molecular Weight	491.01
SMILES	N[C@H]1C2(CCN(C3=NC4=C(N=C(C=C4)SC5=CC=NC(N)=C5Cl)N=C3)CC2)CC6=NC=CC=C61

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.