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SHP2-IN-33

SHP2 Inhibitor

SHP2-IN-33 is an allosteric inhibitor of SHP2, exhibiting an IC50 of 1.2 μM. This compound demonstrates significant antiproliferative activity against Huh7 cells, with an IC50 of 38 μM, by inducing G0/G1 cell cycle arrest and promoting apoptosis while inhibiting the MAPK signaling pathway. In vivo studies utilizing a Huh7 xenograft mouse model reveal substantial antitumor efficacy along with favorable pharmacokinetic properties, including 54% oral bioavailability and a half-life of 10.57 hours. SHP2-IN-33 serves as a valuable tool for investigating tumorigenesis related to SHP2 dysregulation.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	2894017-46-8
Applications	SHP2 Inhibitor
Formula	C₁₆H₁₉Cl₂N₅S
Molecular Weight	384.33
SMILES	ClC1=CC=CC(SC2=C(N)N=C(N(C3CCNCC3)C)C=N2)=C1Cl

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.