Fig. 1 · Structure
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SHP2-IN-37
SHP2 Inhibitor
SHP2-IN-37 is a potent allosteric inhibitor of SHP2, demonstrating a selective binding profile with an IC50 of 0.023 μM. This compound exhibits significant antiproliferative effects on KYSE-520 and MV-411 cancer cell lines, with IC50 values of 6.97 μM and 0.67 μM, respectively. SHP2-IN-37 is valuable for research focused on the modulation of SHP2 signaling pathways and the development of targeted therapies in various cancer models.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 3086289-71-3 |
| Applications | SHP2 Inhibitor |
| Formula | C19H22Cl2N4O2S |
| Molecular Weight | 441.37 |
| SMILES | ClC1=C(Cl)C(SC2=CN=C(N(CC3)CCC43[C@H](N)[C@H](C)OC4)C=[N+]2[O-])=CC=C1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.