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SHP2-IN-44

SHP2 Inhibitor

SHP2-IN-44 is an allosteric inhibitor of SHP2, exhibiting an IC50 of 27 nM. This compound effectively inhibits ERK phosphorylation with an IC50 of 299 nM while demonstrating a lack of off-target activity on hERG channels. SHP2-IN-44 displays broad-spectrum anticancer activity, making it a valuable tool for research into juvenile myelomonocytic leukemia, neuroblastoma, and breast cancer, as well as conditions like Noonan syndrome and LEOPARD syndrome.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	2818955-47-2
Applications	SHP2 Inhibitor
Formula	C₂₂H₂₃ClFN₇S
Molecular Weight	471.98
SMILES	NC[C@@]1(C2=C(C=CC=C2)F)[C@]3([H])[C@@]1([H])CCN(C4=NC(N)=C(N=C4)SC5=CC=NC(N)=C5Cl)C3

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.