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SHP2-IN-46

SHP2 Inhibitor

SHP2-IN-46 is an orally active inhibitor of the SHP2 enzyme, exhibiting an IC50 of 11.76 μM. This compound effectively inhibits SHP2 enzymatic activity, demonstrating significant anti-tumor properties by suppressing cell proliferation in various cancer cell lines. SHP2-IN-46 is a valuable tool for research applications related to lung adenocarcinoma, pancreatic cancer, and hepatoblastoma, facilitating investigations into the role of SHP2 in tumor biology and potential therapeutic strategies.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	3086360-36-0
Applications	SHP2 Inhibitor
Formula	C₁₇H₁₉N₅O
Molecular Weight	309.37
SMILES	CC(C=C1NC2=CC=CC=C2C)=NN1C(N3)=NC(C)=C(C)C3=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.