Fig. 1 · Structure
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SHP2-IN-9
SHP2 Inhibitor
SHP2-IN-9 is a selective inhibitor of SHP2, with an IC50 value of 1.174 μM and enhanced penetration across the blood-brain barrier. It displays an 85-fold preference for SHP2 over SHP1, effectively inhibiting SHP2-mediated cell signaling pathways and cancer cell proliferation. Research applications include the study of cervix cancer and glioblastoma growth in vivo, making it a valuable tool for investigating targeted cancer therapies.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2987135-92-0 |
| Applications | SHP2 Inhibitor |
| Formula | C20H20FN3O2S |
| Molecular Weight | 385.46 |
| SMILES | O=C(NCC1=CC=C(C=C1)F)CN2C=NC3=C(C4=C(S3)CCCCC4)C2=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.