Fig. 1 · Structure
Documents & Downloads
SHP389
SHP2 Inhibitor
SHP389 is an allosteric inhibitor of SHP2, demonstrating an IC50 of 36 nM for both SHP2 and phosphorylated ERK. This compound is valuable in research focused on the modulation of SHP2 activity and its role in signaling pathways, particularly those involved in oncogenesis. Its specificity and potency make it an essential tool for studies investigating SHP2-related mechanisms in disease.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2235394-90-6 |
| Applications | SHP2 Inhibitor |
| Formula | C23H29ClN8O2 |
| Molecular Weight | 484.98 |
| SMILES | O=C1C2=C(C3=C(Cl)C(NC4CC4)=NC=C3)NN=C2N=C(N(CC5)CCC65[C@H](N)[C@H](C)OC6)N1C |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.