Fig. 1 · Structure
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SHP836
SHP2 Inhibitor
SHP836 is an allosteric inhibitor of the SHP2 protein, demonstrating an IC50 value of 12 μM for the full-length enzyme. This compound serves as a crucial tool for studying the role of SHP2 in various cellular processes, including signal transduction and oncogenesis. SHP836 is particularly relevant in the context of cancer research, where modulation of SHP2 activity may impact tumor growth and response to therapies.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1957276-35-5 |
| Applications | SHP2 Inhibitor |
| Formula | C16H19Cl2N5 |
| Molecular Weight | 352.26 |
| SMILES | NC1=NC(N2C[C@@H](C)N[C@@H](C)C2)=NC=C1C3=CC=CC(Cl)=C3Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.