Fig. 1 · Structure
Documents & Downloads
SHP844
SHP2 Inhibitor
SHP844 is a selective SHP2 inhibitor, with an IC50 of 18.9 µM. SHP2 is a protein tyrosine phosphatase that plays a critical role in modulating tyrosine phosphorylation, influencing cellular processes such as proliferation, differentiation, and survival. This compound is valuable for research applications aimed at elucidating SHP2's role in various signaling pathways and its potential as a therapeutic target in cancer and other diseases.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2222280-82-0 |
| Applications | SHP2 Inhibitor |
| Formula | C29H24ClN5O6 |
| Molecular Weight | 573.98 |
| SMILES | O=C(O)[C@H]1N(C(C2=CC=C(CN3C4=NN=C(C5=CC=CC(OC)=C5O)N4C6=C(C=CC=C6)C3=O)C(Cl)=C2)=O)CCC1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.