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SHR168442

Catalog No.: A77587
ROR Modulator
SHR168442 is a selective modulator of retinoid-related orphan receptor gamma (RORγ), exhibiting an IC50 value of 0.035 μM. This compound significantly influences RORγ activity, making it valuable for research applications related to immune response and inflammatory diseases. Its precise modulation of RORγ provides insights into pathways regulated by this receptor, facilitating studies in cellular signaling and potential therapeutic interventions.
SHR168442 2382961-86-4 ROR Modulator
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Size Price Stock Qty
5mg
$795.00
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Research use only. We do not sell to patients.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionSHR168442 is a selective modulator of retinoid-related orphan receptor gamma (RORγ), exhibiting an IC50 value of 0.035 μM. This compound significantly influences RORγ activity, making it valuable for research applications related to immune response and inflammatory diseases. Its precise modulation of RORγ provides insights into pathways regulated by this receptor, facilitating studies in cellular signaling and potential therapeutic interventions.
Product Information
Catalog NumA77587
FormulaC23H25Cl2F2N3O3S
Molecular Weight532.43
CAS Number2382961-86-4
SMILESOCC[C@H](C1=CC=C(C=C1)S(CC)(=O)=O)C2=NC3=CC(Cl)=C(N4CCC(F)(CC4)F)C(Cl)=C3N2
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Endocrinology-Hormones > ROR