Fig. 1 · Structure
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Sigma-1 receptor antagonist 1
σ1 R Antagonist
Sigma-1 Receptor Antagonist 1 (compound 137) is a selective antagonist of the sigma-1 receptor (σ1R), demonstrating a high binding affinity with a Ki value of 1.06 nM. This compound exhibits notable antineuropathic pain activity, making it a promising candidate for research into therapeutic interventions for neuropathic pain. Its specificity for σ1R positions it as a valuable tool in understanding the biological functions and potential clinical applications of sigma-1 receptor modulation.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 1639220-19-1 |
| Applications | σ1 R Antagonist |
| Formula | C19H23Cl2N3O |
| Molecular Weight | 380.31 |
| SMILES | CC1=NC(C2=CC=C(Cl)C=C2)=NC(OCCCN3CCCCC3)=C1Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.