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Sigma-1 receptor antagonist 6

Sigma-1 Receptor Antagonist

Sigma-1 receptor antagonist 6 is a selective antagonist of the Sigma-1 receptor (σ1R), exhibiting significant antiallodynic properties. This compound effectively reduces mechanical allodynia in neuropathic pain models, particularly in response to paclitaxel treatment. Its application in research settings enables the exploration of σ1R modulation in pain pathways and the development of novel analgesic therapies.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Antagonist
CAS Number	1335032-28-4
Applications	Sigma-1 Receptor Antagonist
Formula	C₃₂H₃₄N₆
Molecular Weight	502.65
SMILES	C#CCN(C)C1=NC(NCCCC2CCN(CC3=CC=CC=C3)CC2)=C(C#N)C(C4=CC=CC=C4)=C1C#N

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.