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Sigma-2 Radioligand 1

Sigma-2 Ligand

Sigma-2 Radioligand 1 is a selective ligand targeting the sigma-2 receptor. This radioligand demonstrates favorable biodistribution in murine models and exhibits significant in vivo activity in rat studies. Modified with [18F], Sigma-2 Radioligand 1 is suitable for micro-PET/CT imaging, displaying high tumor uptake and an optimal tumor-to-background ratio, particularly in U87MG glioma xenografts. Its specificity makes it a valuable tool for tumor visualization and research into sigma receptor biology.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Ligand / Binder
CAS Number	2860554-32-9
Applications	Sigma-2 Ligand
Formula	C₂₄H₃₀FN₃O₃
Molecular Weight	427.51
SMILES	FCCN1C(N(C2=C1C=CC=C2)CCCCN3CCC4=C(C3)C=C(C(OC)=C4)OC)=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.