Sigmoidin B is a selective inhibitor of 5-lipoxygenase, targeting the leukotriene synthesis pathway. This prenylated flavanone exhibits significant antioxidant activity by effectively scavenging DPPH radicals. Additionally, Sigmoidin B demonstrates antigenotoxic effects, notably inhibiting genotoxicity induced by Aflatoxin B1 with an IC50 of 18.7 μg/mL, and possesses anti-inflammatory properties. Its diverse biological activities make it a valuable reagent for research in inflammation and oxidative stress-related studies.
Sigmoidin B is a selective inhibitor of 5-lipoxygenase, targeting the leukotriene synthesis pathway. This prenylated flavanone exhibits significant antioxidant activity by effectively scavenging DPPH radicals. Additionally, Sigmoidin B demonstrates antigenotoxic effects, notably inhibiting genotoxicity induced by Aflatoxin B1 with an IC50 of 18.7 μg/mL, and possesses anti-inflammatory properties. Its diverse biological activities make it a valuable reagent for research in inflammation and oxidative stress-related studies.
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