Silvestrol

Catalog No.: A11574

eIF4A inhibitor

Silvestrol

Silvestrol Chemical Structure

CAS NO. 697235-38-4

Silvestrol is a eukaryotic translation initiation factor 4A (eIF4A) inhibitor isolated from the fruits and twigs of Aglaia foveolata. Silvestrol induces autophagy and caspase-mediated apoptosis.

Availability: In stock

Package Price Qty
1 mg
$720.00
5 mg
$2,160.00
10 mg
$3,680.00
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Biological Activity

Silvestrol is a eukaryotic translation initiation factor 4A (eIF4A) inhibitor isolated from the fruits and twigs of Aglaia foveolata. Silvestrol induces autophagy and caspase-mediated apoptosis.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 15.28 mL 76.38 mL 152.75 mL
0.5 mM 3.06 mL 15.28 mL 30.55 mL
1 mM 1.53 mL 7.64 mL 15.28 mL
5 mM 0.31 mL 1.53 mL 3.06 mL

*The above data is based on the productmolecular weight 654.66. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A11574
Actions Inhibitor
CAS No. 697235-38-4
Formula C34H38O13
M. Wt 654.66
Purity >98%
Synonyms (-)-Silvestrol
SMILES O=C([[email protected]]([[email protected]]1C2=CC=CC=C2)[[email protected]@H](O)[[email protected]]3(O)[[email protected]@]1(C4=CC=C(OC)C=C4)OC5=CC(O[[email protected]@H]6O[[email protected]@H]([[email protected]](O)CO)CO[[email protected]]6OC)=CC(OC)=C35)OC
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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