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Simocyclinone D8

DNA Gyrase Inhibitor

Simocyclinone D8 is a potent DNA gyrase inhibitor that exhibits significant antibacterial and antitumor activity, particularly against Gram-positive bacteria. By targeting DNA gyrase, it disrupts essential DNA processes, leading to inhibition of proliferation in multiple tumor cell lines. This compound is suitable for research applications investigating bacterial resistance and cancer therapeutics.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	301845-97-6
Applications	DNA Gyrase Inhibitor
Formula	C₄₆H₄₂ClNO₁₈
Molecular Weight	932.27
SMILES	O[C@@]12[C@@]34[C@@]([C@@H](C5=C(O)C([C@H]6C[C@H]([C@H](OC(C)=O)[C@@H](C)O6)OC(/C=C/C=C/C=C/C=C/C(NC7=C(C8=CC=C(O)C(Cl)=C8OC7=O)O)=O)=O)=CC=C5C4=O)O)([C@@H](O)C[C@@]1(CC(C)=CC2=O)O)O3

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.