Siramesine fumarate is a potent sigma-2 receptor agonist with a subnanomolar affinity for sigma-2 receptors (IC50 = 0.12 nM) and a 140-fold selectivity over sigma-1 receptors (IC50 = 17 nM). This compound induces cell death through the destabilization of mitochondria without affecting lysosomes. Siramesine fumarate has demonstrated significant anti-cancer activity, making it a valuable tool for research in cancer therapeutics and the study of sigma receptor biology.
Siramesine fumarate is a potent sigma-2 receptor agonist with a subnanomolar affinity for sigma-2 receptors (IC50 = 0.12 nM) and a 140-fold selectivity over sigma-1 receptors (IC50 = 17 nM). This compound induces cell death through the destabilization of mitochondria without affecting lysosomes. Siramesine fumarate has demonstrated significant anti-cancer activity, making it a valuable tool for research in cancer therapeutics and the study of sigma receptor biology.
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