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Biological Activity
SJB3-019A is a potent and novel usp1 inhibitor. SJB3-019A (IC50 = 0.0781 uM) was 5 times more potent than SJB2-043 in promoting ID1 degradation and cytoxicity in K562 cells.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 36.2 mL | 181 mL | 361.99 mL |
| 0.5 mM | 7.24 mL | 36.2 mL | 72.4 mL |
| 1 mM | 3.62 mL | 18.1 mL | 36.2 mL |
| 5 mM | 0.72 mL | 3.62 mL | 7.24 mL |
*The above data is based on the productmolecular weight 276.25. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A12822 |
|---|---|
| Actions | Inhibitor |
| CAS No. | N /A |
| Formula | C16H8N2O3 |
| M. Wt | 276.25 |
| Purity | >98% |
| SMILES | O=C(C1=C2OC(C3=CN=CC=C3)=N1)C4=CC=CC=C4C2=O |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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