SKL2001 is an agonist of the Wnt/β-catenin pathway, with anti-cancer activity. SKL2001 stabilizes intracellular β-catenin via disruption of the Axin/β-catenin interaction.
SKL2001 is an agonist of the Wnt/β-catenin pathway, with anti-cancer activity. SKL2001 stabilizes intracellular β-catenin via disruption of the Axin/β-catenin interaction.
Product Information
Catalog Num
A16707
Formula
C14H14N4O3
Molecular Weight
286.29
CAS Number
909089-13-0
SMILES
O=C(C1=NOC(C2=CC=CO2)=C1)NCCCN3C=CN=C3
Synonyms
SKL 2001, SKL-2001
Storage
Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 1 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
Solubility
In vitro (25°C)
DMSO
50 mg/mL (174.64 mM)
Water
Insoluble
Ethanol
50 mg/mL (174.64 mM)
In vivo
2% DMSO+40% PEG 300+2% Tween 80+ddH2O
6 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
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