Fig. 1 · Structure
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Skp2 inhibitor 2
Skp2 Inhibitor
Skp2 Inhibitor 2 selectively targets S-phase kinase-associated protein 2 (Skp2), demonstrating an IC50 value of 570 nM in the Skp2-Cks1 complex. As a crucial component of the cullin-RING ligase complex, Skp2 plays a significant role in the ubiquitination of substrates, mediating both proteolytic and non-proteolytic processes. This compound is valuable for research focused on cell cycle regulation and the mechanisms of ubiquitin-proteasome system modulation.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2760612-77-7 |
| Applications | Skp2 Inhibitor |
| Formula | C27H32N4O |
| Molecular Weight | 428.57 |
| SMILES | O=C(C(C)(C)C)NCC1CCN(CC1)C2=NC(C3=CC=CC=C3)=C(C4=CC=CC=C4)N=C2 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.