SMARCA2-IN-4 is a selective inhibitor of the SWI/SNF chromatin remodeling complex, specifically targeting the bromodomains of SMARCA proteins. This compound demonstrates high binding affinity for PB1, SMARCA2B, and SMARCA4, with dissociation constants (Kd) of 124 nM, 262 nM, and 417 nM, respectively. SMARCA2-IN-4 is valuable for studies investigating the roles of chromatin remodeling in gene expression and cellular processes, offering potential insights into cancer biology and epigenetic regulation.
SMARCA2-IN-4 is a selective inhibitor of the SWI/SNF chromatin remodeling complex, specifically targeting the bromodomains of SMARCA proteins. This compound demonstrates high binding affinity for PB1, SMARCA2B, and SMARCA4, with dissociation constants (Kd) of 124 nM, 262 nM, and 417 nM, respectively. SMARCA2-IN-4 is valuable for studies investigating the roles of chromatin remodeling in gene expression and cellular processes, offering potential insights into cancer biology and epigenetic regulation.
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