SMARCA2-IN-6 is a potent inhibitor of SMARCA2 and SMARCA4, exhibiting IC50 values under 5 nM for both targets. This compound effectively suppresses KRT80 gene expression in H1299 cells with an IC50 of 26 nM, and demonstrates significant antiproliferative effects in BRG1-mutant SKMEL5 cells, with an IC50 of 13 nM. SMARCA2-IN-6 serves as a valuable tool for research applications focused on chromatin remodeling and associated oncogenic pathways.
SMARCA2-IN-6 is a potent inhibitor of SMARCA2 and SMARCA4, exhibiting IC50 values under 5 nM for both targets. This compound effectively suppresses KRT80 gene expression in H1299 cells with an IC50 of 26 nM, and demonstrates significant antiproliferative effects in BRG1-mutant SKMEL5 cells, with an IC50 of 13 nM. SMARCA2-IN-6 serves as a valuable tool for research applications focused on chromatin remodeling and associated oncogenic pathways.
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