Fig. 1 · Structure
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SMD-3040 intermediate-2
Intermediate
SMD-3040 intermediate-2 is a crucial intermediate in the synthesis of SMD-3040, a selective degrader of SMARCA2. This compound is designed for use in antibody-drug conjugate (ADC) synthesis and demonstrates significant tumor growth inhibition in xenograft models. Its chemical structure includes SMARCA2/4 ligands, a linker, and VHL ligands, making it a valuable tool for researchers investigating targeted degradation strategies in cancer therapy.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 2632308-00-8 |
| Applications | Intermediate |
| Formula | C21H28ClN3O2 |
| Molecular Weight | 389.92 |
| SMILES | N#CC1=CC=C(N2CC3(CC2C)CCN(CC3)C(OC(C)(C)C)=O)C=C1Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.