Fig. 1 · Structure
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Smurf1-IN-1
SMURF1Inhibitor
Smurf1-IN-1 is a selective inhibitor of SMURF1, an E3 ubiquitin protein ligase, with an IC50 of 92 nM. This compound demonstrates significant efficacy in animal models of pulmonary hypertension. It is a valuable tool for research focused on the role of ubiquitination in cellular processes and its implications in various diseases.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1824708-03-3 |
| Applications | SMURF1Inhibitor |
| Formula | C24H29ClN6O2 |
| Molecular Weight | 468.98 |
| SMILES | O=C(C1=C(C)N(C2=CC=C(C3CC3)C=C2Cl)N=N1)NC4=C(C)N(C)N(C5CCCCC5)C4=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.