Fig. 1 · Structure
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Sodium new houttuyfonate
NDM-1 Inhibitor
Sodium new houttuyfonate is a partially reversible inhibitor of New Delhi metallo-beta-lactamase-1 (NDM-1), exhibiting an IC50 value of 14.2 μM. This compound also demonstrates inhibitory activity against renin and angiotensin I converting enzyme (ACE). Sodium new houttuyfonate has potential applications in restoring the antibacterial efficacy of Meropenem against antibiotic-resistant E. coli strains harboring the blaNDM-1 gene, making it a valuable tool in combating multidrug-resistant infections.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 112714-99-5 |
| Applications | NDM-1 Inhibitor |
| Formula | C14H27NaO5S |
| Molecular Weight | 330.42 |
| Synonyms | SNH |
| SMILES | O=S(C(O)CC(CCCCCCCCCCC)=O)(O[Na])=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.