Fig. 1 · Structure
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Solimastat
MMP Inhibitor
Solimastat is a potent metalloproteinase (MMP) inhibitor that effectively blocks both constitutive and antibody-stimulated shedding of CD30 from cell surfaces, exhibiting an IC50 of 180 nM. This compound enhances the persistence of the anti-CD30 antibody Ki-3 on targeted cells and promotes its internalization. Additionally, Solimastat increases the cytotoxicity of Ki-3.dgA towards CD30+ L540 cells. It serves as a valuable reagent for research focused on CD30+ malignancies.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 226072-63-5 |
| Applications | MMP Inhibitor |
| Formula | C20H32N4O5 |
| Molecular Weight | 408.50 |
| Synonyms | BB-3644 |
| SMILES | [C@@H]([C@@H](C(NO)=O)OC)(C(N[C@H](C(NC1=CC=CC=N1)=O)[C@@](C)(C)C)=O)CC(C)C |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.