Spantide I is a selective antagonist of the neurokinin-1 (NK1) receptor, demonstrating Ki values of 230 nM for NK1 and 8150 nM for NK2 receptors. This compound effectively modulates cytokine profiles by reducing type 1 and enhancing type 2 cytokine IL-10 in the infected cornea, thereby significantly decreasing corneal perforation. Spantide I serves as a valuable tool in research focused on inflammatory responses and therapeutic interventions in corneal diseases.
Spantide I is a selective antagonist of the neurokinin-1 (NK1) receptor, demonstrating Ki values of 230 nM for NK1 and 8150 nM for NK2 receptors. This compound effectively modulates cytokine profiles by reducing type 1 and enhancing type 2 cytokine IL-10 in the infected cornea, thereby significantly decreasing corneal perforation. Spantide I serves as a valuable tool in research focused on inflammatory responses and therapeutic interventions in corneal diseases.
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