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Spantide II

Catalog No.: A61983
NK-1R Antagonist
Spantide II is a potent neurokinin-1 receptor (NK-1R) antagonist, functioning as an undecapeptide analog of substance P. By binding to NK-1R, Spantide II effectively inhibits the proinflammatory activities associated with substance P. This reagent is valuable for research into inflammatory skin disorders, including psoriasis and contact dermatitis, contributing to the understanding of neurogenic inflammation.
Spantide II 129176-97-2 NK-1R Antagonist
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Size Price Stock Qty
5mg
$235.00
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10mg
$385.00
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Research use only. We do not sell to patients.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionSpantide II is a potent neurokinin-1 receptor (NK-1R) antagonist, functioning as an undecapeptide analog of substance P. By binding to NK-1R, Spantide II effectively inhibits the proinflammatory activities associated with substance P. This reagent is valuable for research into inflammatory skin disorders, including psoriasis and contact dermatitis, contributing to the understanding of neurogenic inflammation.
Product Information
Catalog NumA61983
FormulaC86H104Cl2N18O13
Molecular Weight1668.76
CAS Number129176-97-2
SMILESC([C@H](C(N[C@H](C(N[C@H](CC=1C=2C(NC1)=CC=CC2)C(N[C@H](C(N[C@@H](CCCC)C(N)=O)=O)CC(C)C)=O)=O)CC3=CC=CC=C3)=O)NC([C@@H](NC([C@@H](CC4=CC(Cl)=C(Cl)C=C4)NC(=O)[C@H]5N(C([C@@H](NC(=O)[C@H]6N(C([C@@H](CCCCNC(=O)C=7C=CC=NC7)N)=O)CCC6)CC=8C=CC=NC8)=O)CCC5)=O)CC(N)=O)=O)C=9C=%10C(NC9)=CC=CC%10
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GPCR/G Protein > Neurokinin Receptors