Spautin-1

Catalog No.: A12942
Autophagy Inhibitor
Spautin-1 is a novel autophagy inhibitor, IM inhibited the growth of K562 cells with IC50 of 1.03μM. In contrast, co-treatment with Spautin-1 increased IM-induced inhibition of cell viability with IC50 of 0.45 μM.
Grouped product items
Product Name Price Stock Qty
Spautin-1 10mg
$70.00
In stock
Spautin-1 25mg
$130.00
In stock
Spautin-1 50mg
$250.00
In stock
Bulk Size
Bulk Discount
Free Delivery on orders over $500

Important Notice: For research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Adooq's Spautin-1 has been cited by 2 publications
  • Bopei Cui, .et al. , Signal Transduct Target Ther, 2023, Sep 25;8(1):366 PMID: 37743418
  • Yoon-Jin Kim, .et al. , Sci Adv, 2021, Feb 19;7(8) PMID: 33608268
  • Biological Activity
    Discription Spautin-1 is a novel autophagy inhibitor, IM inhibited the growth of K562 cells with IC50 of 1.03μM. In contrast, co-treatment with Spautin-1 increased IM-induced inhibition of cell viability with IC50 of 0.45 μM.
    Targets
    Target Value
    Product Information
    Catalog Num A12942
    Formula C15H11F2N3
    Molecular Weight 271.26
    CAS Number 1262888-28-7
    SMILES FC1=CC(C(NCC2=CC=C(F)C=C2)=NC=N3)=C3C=C1
    Synonyms Spautin 1, Spautin1
    Storage

    Store lyophilized at -20ºC, keep desiccated.
    In lyophilized form, the chemical is stable for 36 months.
    In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

    Solubility
    In vitro DMSO 51 mg/mL (188.01 mM)
    Water Insoluble
    Ethanol 7 mg/mL (25.8 mM)
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Preparing Stock Solutions
    Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
    0.1 mM 36.87 mL 184.33 mL 368.65 mL
    0.5 mM 7.37 mL 36.87 mL 73.73 mL
    1 mM 3.69 mL 18.43 mL 36.87 mL
    5 mM 0.74 mL 3.69 mL 7.37 mL
    Useful Calculator

    This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

    Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

    • Mass

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      Molecular Weight

    Please check COA/MSDS for correct molecular weight.

    Calculate the dilution required to prepare a stock solution.
    This equation is commonly abbreviated as: C1V1 = C2V2

    • C1

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